GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs801193 | 1 | rs4279493 | chr7:66226620 | TYW1 | chr7:66461817-66704496:+ | 0.18 | 3.89 | 0.000116 | Aortic root size |
| THCA | cis | rs41997 | 1 | rs4279530 | chr7:118070771 | ANKRD7 | chr7:117864712-117882782:+ | -0.27 | -4.47 | 9.57E-6 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs4280164 | 1 | rs4280164 | chr14:24771285 | ADCY4 | chr14:24787571-24804277:- | 0.23 | 6.76 | 4.12E-11 | Parent of origin effect on language impairment (paternal) |
| THCA | cis | rs4280164 | 1 | rs4280164 | chr14:24771285 | LTB4R | chr14:24780705-24787061:+ | -0.3 | -5.39 | 1.11E-7 | Parent of origin effect on language impairment (paternal) |
| THCA | cis | rs4280164 | 1 | rs4280164 | chr14:24771285 | LTB4R2 | chr14:24778161-24781259:+ | -0.25 | -3.95 | 9.1E-5 | Parent of origin effect on language impairment (paternal) |
| THCA | cis | rs4280164 | 1 | rs4280164 | chr14:24771285 | RABGGTA | chr14:24734746-24740803:- | -0.16 | -3.6 | 0.000355 | Parent of origin effect on language impairment (paternal) |
| THCA | cis | rs3853750 | 1 | rs4280918 | chr5:110162078 | TMEM232 | chr5:109624934-110062381:- | 0.2 | 4.01 | 7.14E-5 | Asthma and hay fever |
| THCA | cis | rs2273 | 1 | rs4282209 | chr4:76919536 | NAAA | chr4:76831809-76862166:- | -0.33 | -6.54 | 1.61E-10 | Longevity |
| THCA | cis | rs6988636 | 1 | rs4282551 | chr8:124185916 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.19 | 3.33E-5 | Urinary uromodulin levels |
| THCA | cis | rs10760706 | 1 | rs4282626 | chr9:102690180 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.33 | 1.86E-5 | Alopecia areata |
| THCA | cis | rs9858542 | 1 | rs4283605 | chr3:49678651 | MST1 | chr3:49721381-49726196:- | 0.13 | 3.77 | 0.000183 | Crohn's disease;Ulcerative colitis |
| THCA | cis | rs10043228 | 1 | rs4283834 | chr5:115521463 | COMMD10 | chr5:115420727-115628978:+ | 0.48 | 5.84 | 9.44E-9 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs428445 | 1 | rs428445 | chr20:55036547 | C20orf43 | chr20:55043647-55093942:+ | -0.29 | -7.75 | 5.4E-14 | Refractive astigmatism |
| THCA | cis | rs428445 | 1 | rs428445 | chr20:55036547 | CSTF1 | chr20:54967427-54979582:+ | -0.16 | -3.37 | 0.000823 | Refractive astigmatism |
| THCA | cis | rs4285028 | 1 | rs4285028 | chr3:121660664 | IQCB1 | chr3:121488610-121553926:- | -0.36 | -6.56 | 1.43E-10 | Multiple sclerosis |